Selective inhibition by 2-heptyl-4-hydroxyquinoline N-oxide of certain oxidation-reduction reactions

Selective inhibition by 2-heptyl-4-hydroxyquinoline N-oxide of certain oxidation-reduction reactions.

Effect of 2-n-heptyl-4-hydroxyquinoline N-oxide on proton permeability of the mitochondrial membrane.

The respiratory-chain inhibitor 2-n-heptyl-4-hydroxyquinoline N-oxide catalyses transmembrane proton transport driven by a pH gradient in isolated rat liver mitochondria. This effect explains the apparent blockade of net proton translocation by this compound in mitochondria respiring with ferrocyanide as described by Papa, Lorusso, Guerrieri, Boffoli, Izzo & Capuano [(1977) in Bioenergetics of ...

Interaction of 2-n-heptyl-4-hydroxyquinoline-N-oxide with dimethyl sulfoxide reductase of Escherichia coli.

We have studied the interaction of the menaquinol analog 2-n-heptyl-4-hydroxyquinoline-N-oxide (HOQNO) with dimethyl sulfoxide reductase (DmsABC) and the effect of a mutation in the DmsC subunit (DmsABCH65R) using fluorescence titration and stopped-flow methods. The titration data show that the HOQNO fluorescence is quenched when HOQNO binds to DmsABC. The binding stoichiometry is determined to...

Inhibition of dihydrocozymase-oxidase activity of heart-muscle preparations and of certain cell-free bacterial preparations by 2-heptyl-4-hydroxyquinoline N-oxide.

a preliminary communication (Jackson & Lightbown, 1956) we have reported the inhibitory effect of heptyl N-oxide on the dihydrocozymaseoxidase activities of heart-muscle succinic oxidase preparations and of certain cell-free preparations of Staphylococcus aureus, Eacherichia coli, Proteus vulgariw and Bacillus pumilu&. The present paper includes a more detailed account of this work, together wi...

Studies on lipoxygenase inhibitors. II. KF8940 (2-n-heptyl-4-hydroxyquinoline-N-oxide), a potent and selective inhibitor of 5-lipoxygenase, produced by Pseudomonas methanica.

Pseudomonas methanica KY4634 was found to produce 5-lipoxygenase inhibitor designated KF8940, MY12-62a and MY12-62c. The inhibitors were purified by solvent extraction, silica gel column chromatography, reversed-phase low pressure liquid chromatography and crystallization. The chemical structures of KF8940, MY12-62a and MY12-62c were determined to be 2-n-heptyl-4-hydroxyquinoline-N-oxide, 2-n-h...